Scientific Publications (Patents, Papers and Slides)

PETsys technology was developed since 2003 based in APDs (Avalanche Photo Diodes), as photo sensors, and it was updated in 2011 using SiPM (Silicon Photomultipliers).

For the current stage of our technology (SiPM), these are the relevant patent applications:

Provisional Patent Request for SiPM readout apparatus
  • Portugal (INPI - process n. 01 106650) / 19-11-2012

Patent Requests for SiPM readout apparatus:

  • PCT (Pedido nº 6832X / 3197 – 2013/11/18 – PTI)
  • Portugal (Pedido nº 20131000083889 / 0171 - 2013/11/19 – PAT)

Granted:
Country / Publication Number / Publication Date / Status / Annex / Patent Number

  • Portugal / PT103200 / 31-10-2006 / Granted / PT_01 / PT103200
  • USA / US20080103391A1 / 01-05-2008 / Granted / / US. 7,917,192
National phase:
  • PCT / WO2006049523A3 / 15-02-2007

Under local examination:

  • EU / EP1794622A2 / 13-06-2007
  • Australia / AU2005301414A1 / 11-05-2006
  • Brazil / BR200516866A / 23-09-2008
  • Japan / JP2008514952T / 08-05-2008
  • Russia / RU2007110488
1. Experimental results with TOFPET2 ASIC for time-f-flight applications
Authors: Ricardo Bugalho, Agostino Di Francesco, Luis Ferramacho, Carlos Leong, Tahereh Niknejad, Luis Oliveira, Luca Pacher, Manuel Rolo, Angelo Rivetti, Miguel Silveira, Jose C. Silva, Rui Silva, Stefaan Tavernier, João Varela
Journal: Nuclear Instruments and Methods, 912, 21 December 2018, Pages 195-198
 
Authors: Tahereh Niknejad, Marco Pizzichemi, Gianluca Stringhini, Etiennette Auffray, Ricardo Bugalho, Jose Carlos Rasteiro Da Silvai, Agostino Di Francesco, Luis Ferramacho, Paul Lecoq, Carlos Leong, Marco Paganoni, Manuel Rolo, Rui Silva, Miguel Silveira, Stefaan Tavernier, João Varela, Carlos Zorraquino
Journal: Nuclear Instruments and Method, Volume 845, 11 February 2017, Pages 684-688
 
3. Development of a high-resolution module for PET scanners
Authors: G. Stringhini, M. Pizzichemi, A. Ghezzi, A. Stojkovic, S. Tavernier, T. Niknejad, João Varela, M. Paganoni and E. Auffray ,
Journal: 2017 JINST 12 C02073
 
Authors: A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, J.C. Silva, R. Silva, and J. Varela,
Journal of Instrumentation, Volume 11, March 2016
 
5. A new method for depth of interaction detrmination in PET dtectors
Authors: M. Pizzichemi, G. Stringhini, T. Niknejad, Z. Liu1, P. Lecoq, S. Tavernier, J. Varela, M. Paganoni, E. Auffray.
Journal: Physics in Medicine and Biology, March 2016, Volume 61, Number 12
 
Authors: Tahereh Niknejad, Saeed Setayeshi, Stefaan Tavernier, Ricardo Bugalho, Luis Ferramacho, Agostino Di Francesco, Carlos Leong, Manuel Dionísio Rolo, Mahnaz Shamshirsaz, José C. Silva, Rui Silva, Miguel Silveira, Carlos Zorraquino, Joao Varela, 
Journal of Instrumentation; December 2016; 11(12):P12003; DOI: 10.1088/1748-0221/11/12/P12003
 
Authors: G. Cucciati, E. Auffray, R. Bugalho, L. Cao, N. Di Vara, F. Farina, N. Felix, B. Frisch, A. Ghezzi, V. Juhan, D. Jun, P. Lasaygues, P. Lecoq, S. Mensah, O. Mundler, J. Neves, M. Paganoni, J. Peter, M. Pizzichemi, P. Siles, J.C. Silva, R. Silva, S. Tavernier, L. Tessonnier, J. Varela.
Journal: 2014 JINST 9 C03008 doi:10.1088/1748-0221/9/03/C03008.
 

8. TOFPET ASIC for PET applications (PDF)
Author(s): Rolo, M. D.; Bugalho, R.; Goncalves, F.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C02050 DOI: 10.1088/1748-0221/8/02/C02050 Published: FEB 2013

9. EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography (PDF)
Author(s): Aubry, N.; Auffray, E.; Mimoun, F. B.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C04002 DOI: 10.1088/1748-0221/8/04/C04002 Published: APR 2013

10. Combining endoscopic ultrasound with Time-Of-Flight PET: The EndoTOFPET-US Project, EndoTOFPET-US Collaboration, 2013. 4 pp. (PDF)
Published in Nucl.Instrum.Meth. A732 (2013) 577-580
DOI: 10.1016/j.nima.2013.05.027

11. EndoTOFPET-US data acquisition system (PDF)
Author(s): Bugalho, R.; Gaston, C.; Rolo, M. D.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C02049 DOI: 10.1088/1748-0221/8/02/C02049 Published: FEB 2013

12. Feasibility and electromagnetic compatibility study of the ClearPEM front-end electronics for simultaneous PET-MR imaging (PDF)
Author(s): Neves, J. A.; Bugalho, R.; Gruetter, R.; et al.
Source: NUCLEAR INSTRUMENTS & METHODS, Volume: 702 Pages: 34-36 

-Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator, Tahereh Niknejad, Saeed Setayeshi, Stefaan Tavernier, Ricardo Bugalho, Luis Ferramacho, Agostino Di Francesco, Carlos Leong,, Manuel Dionísio Rolo, Mahnaz Shamshirsaz, José C. Silva, Rui Silva, Miguel Silveira, Carlos Zorraquino, Joao Varela, Prepared for submission to JINST, 2016

-Study on Coincidence Time Resolution with SiPM and TOFPET-ASIC utilizing LYSO, GAGG and GFAG, H.V. Wachtera, F.R. Schneiderb, L. Ferramachoc, S. Tavernierc, J. Varelac, R. Fojtb, F. Kreupla, IEEE 2016, Strasbourg

-A new method for depth of interaction determination in PET detectors, M Pizzichemi, G Stringhini, T Niknejad, Z Liu, P Lecoq, S Tavernier, J Varela, M Paganoni and E Auffray, Institute of Physics and Engineering in Medicine, 2016

-Asymmetric Data Acquisition System for an Endoscopic PET-US Detector, Carlos Zorraquino, Ricardo Bugalho, Manuel Rolo, Jose C. Silva, Viesturs Vecklans, Rui Silva, Catarina Ortigão, Jorge A. Neves, Stefaan Tavernier, Pedro Guerra, Andres Santos and João Varela, IEEE 2015, San Diego CA

-TOFPET2: a high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications, A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, J.C. Silva, R. Silva and J. Varela, Topical Workshpo on Electronics for Particle Physics, 2015, Sep28-Oct2, Lisbon

-A Compact Detector Module for Time of Flight PET and the Associated DAQ system (PDF). , Ricardo Bugalho, Katayoun Doroud, Agostino Di Francesco, Jorge Neves, Tahereh Niknejad, Catarina Ortigão, Manuel Dionísio Rolo, José C. Silva, Rui Silva, Stefaan Tavernier, Viesturs Veckalns, Carlos Zorraquino, Joao Varela, IEEE conference on Nuclear science and medical imaging, 2014, Seatle WA.

-Design and Performance of an ASIC for TOF applications (PDF), Ricardo Bugalho, Manuel Dionisio Rolo, Carlos Zorraquino, Rui Silva, Jose C. Silva, Richard Wheadon, Angelo Rivetti, Stefaan Tavernier, Joao Varela, Viesturs Veckalns, IEEE conference on Nuclear science and medical imaging, 2013, Seoul, Korea

-A 64-channel ASIC for TOFPET applicattions (PDF), M D Rolo, R Bugalho, F Gonçalves, G Mazza, A Rivetti, J C Silva, R Silva and J Varela, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Image-based data corrections for Positron Emission Mammography (PDF), Nuno C. Ferreira, Fabiana Rodrigues, Luís Martins, Catarina Ortigão, Francisco Caramelo, Luís Mendes, Cláudia S. Ferreira, Pedro Almeida, Miguel Castelo-Branco, and João Varela, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Random Correction Method for Positron Emission Mammography Using Delayed Coincidence Data, Liji Cao, Ricardo Bugalho, Catarina Ortigao, Joao Varela, and Jorg Peter, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Breast Cancer Diagnosis: First Clinical Results with ClearPEM-Sonic, the Multimodal Positron Emission Mammograph and Ultrasound Scanner, Tessonnier, L.; Siles, P.; Frisch, B.; et al. October 2012. Publication of the abstract in a special series of the EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING: abstract book for the Annual Congress of the EANM 2012, Milan, Italy (Volume: 39 Supplement: 2 Pages: S295-S296 Meeting Abstract: OP696 Published: OCT 2012).

-ClearPEM scanners: performance results and studies in preclinical environment, M. Abrantes, P. Almeida, F. Botelho, R. Bugalho, S. Carvalho, C. S. Ferreira, N. C. Ferreira, M. V. Martins, N. Matela, J. A. Neves, C. Ortigão, A. Rodrigues,A.S. Rodrigues, M. Rolo, J. C. Silva, R. Silva, J. Varela, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-List-Mode Maximum-Likelihood Reconstruction for the ClearPEM System, Liji Cao, Ricardo Bugalho, Nuno Matela, Mónica Martins, Pedro Almeida, Jorg Peter, and Joao Varela, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-Assessment of DOI Resolution in a Fully Mounted PEM Scanner (PDF), N. Matela, C. S. Ferreira1, M. V. Martins, R. Bugalho, J. A. Neves, C. Ortigão, N. Oliveira, J. Varela, P. Almeida, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-Characterization of the Clear-PEM Breast Imaging Scanner Performance, E. Albuquerque et al., IEEE09 Nuclear Science Symposium and Medical Imaging Conference, Orlando, October 25-31, 2009

-Development of component-based normalization correction for the Clear-PEM system (PDF), C. Guerreiro, N. C. Ferreira, R. Bugalho, A. Trindade, N. Matela, M. V. Martins, L. Mendes, C. S. Ferreira, P. Almeida, J. Varela, IEEE09 Nuclear Science Symposium and Medical Imaging Conference, Orlando, October 25-31, 2009

-High-Speed Data Acquisition Electronics for a PEM Scanner (PDF), P. Lousã et al., IEEE NPSS Real Time Conference, May 10-15, 2009, Beijing, China

-Performance Evalution of a Highly Integrated ADP/ASIC Double Readout Supermodule with 768 Channels for Clear-PEM, E. Albuquerque et al., IEEE08 Nuclear Science Symposium and Medical Imaging Conference, Dresden, October 20-24, 2008