Scientific Publications (Patents, Papers and Slides)

PETsys technology was developed since 2003 based in APDs (Avalanche Photo Diodes), as photo sensors, and it was updated in 2011 using SiPM (Silicon Photomultipliers).

For the current stage of our technology (SiPM), these are the relevant patent applications:

Provisional Patent Request for SiPM readout apparatus
  • Portugal (INPI - process n. 01 106650) / 19-11-2012

Patent Requests for SiPM readout apparatus:

  • PCT (Pedido nº 6832X / 3197 – 2013/11/18 – PTI)
  • Portugal (Pedido nº 20131000083889 / 0171 - 2013/11/19 – PAT)

Granted:
Country / Publication Number / Publication Date / Status / Annex / Patent Number

  • Portugal / PT103200 / 31-10-2006 / Granted / PT_01 / PT103200
  • USA / US20080103391A1 / 01-05-2008 / Granted / / US. 7,917,192
National phase:
  • PCT / WO2006049523A3 / 15-02-2007

Under local examination:

  • EU / EP1794622A2 / 13-06-2007
  • Australia / AU2005301414A1 / 11-05-2006
  • Brazil / BR200516866A / 23-09-2008
  • Japan / JP2008514952T / 08-05-2008
  • Russia / RU2007110488

1. TOFPET ASIC for PET applications (PDF)
Author(s): Rolo, M. D.; Bugalho, R.; Goncalves, F.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C02050 DOI: 10.1088/1748-0221/8/02/C02050 Published: FEB 2013

2. EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography (PDF)
Author(s): Aubry, N.; Auffray, E.; Mimoun, F. B.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C04002 DOI: 10.1088/1748-0221/8/04/C04002 Published: APR 2013

3. Combining endoscopic ultrasound with Time-Of-Flight PET: The EndoTOFPET-US Project, EndoTOFPET-US Collaboration, 2013. 4 pp. (PDF)
Published in Nucl.Instrum.Meth. A732 (2013) 577-580
DOI: 10.1016/j.nima.2013.05.027

4. EndoTOFPET-US data acquisition system (PDF)
Author(s): Bugalho, R.; Gaston, C.; Rolo, M. D.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 8 Article Number: C02049 DOI: 10.1088/1748-0221/8/02/C02049 Published: FEB 2013

5. Feasibility and electromagnetic compatibility study of the ClearPEM front-end electronics for simultaneous PET-MR imaging (PDF)
Author(s): Neves, J. A.; Bugalho, R.; Gruetter, R.; et al.
Source: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT Volume: 702 Pages: 34-36 DOI: 10.1016/j.nima.2012.08.033 Published: FEB 21 2013

6. The ClearPEM breast imaging scanner (PDF)
Author(s): Neves, Jorge A.
Group Author(s): ClearPEM Collaboration
Source: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT Volume: 628 Issue: 1 Pages: 444-447 DOI: 10.1016/j.nima.2010.07.021 Published: FEB 1 2011

7. Experimental characterization of the 192 channel Clear-PEM frontend ASIC coupled to a multi-pixel APD readout of LYSO:Ce crystals (PDF)
Author(s): Albuquerque, Edgar; Bexiga, Vasco; Bugalho, Ricardo; et al.
Source: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT Volume: 598 Issue: 3 Pages: 802-814 DOI: 10.1016/j.nima.2008.10.005 Published: JAN 21 2009

8. Experimental characterization of the Clear-PEM scanner spectrometric performance (PDF)
Author(s): Bugalho, R.; Carrico, B.; Ferreira, C. S.; et al.
Source: JOURNAL OF INSTRUMENTATION Volume: 4 Article Number: P10011 DOI: 10.1088/1748-0221/4/10/P10011 Published: OCT 2009

9. Performance and quality control of Clear-PEM detector modules (PDF)
Author(s): Amaral, Pedro; Carrico, Bruno; Ferreira, Miguel; et al.
Source: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT Volume: 580 Issue: 2 Pages: 1123-1126 DOI: 10.1016/j.nima.2007.06.071 Published: OCT 1 2007

-Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator, Tahereh Niknejad, Saeed Setayeshi, Stefaan Tavernier, Ricardo Bugalho, Luis Ferramacho, Agostino Di Francesco, Carlos Leong,, Manuel Dionísio Rolo, Mahnaz Shamshirsaz, José C. Silva, Rui Silva, Miguel Silveira, Carlos Zorraquino, Joao Varela, Prepared for submission to JINST, 2016

-Study on Coincidence Time Resolution with SiPM and TOFPET-ASIC utilizing LYSO, GAGG and GFAG, H.V. Wachtera, F.R. Schneiderb, L. Ferramachoc, S. Tavernierc, J. Varelac, R. Fojtb, F. Kreupla, IEEE 2016, Strasbourg

-A new method for depth of interaction determination in PET detectors, M Pizzichemi, G Stringhini, T Niknejad, Z Liu, P Lecoq, S Tavernier, J Varela, M Paganoni and E Auffray, Institute of Physics and Engineering in Medicine, 2016

-Asymmetric Data Acquisition System for an Endoscopic PET-US Detector, Carlos Zorraquino, Ricardo Bugalho, Manuel Rolo, Jose C. Silva, Viesturs Vecklans, Rui Silva, Catarina Ortigão, Jorge A. Neves, Stefaan Tavernier, Pedro Guerra, Andres Santos and João Varela, IEEE 2015, San Diego CA

-TOFPET2: a high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications, A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, J.C. Silva, R. Silva and J. Varela, Topical Workshpo on Electronics for Particle Physics, 2015, Sep28-Oct2, Lisbon

-A Compact Detector Module for Time of Flight PET and the Associated DAQ system (PDF). , Ricardo Bugalho, Katayoun Doroud, Agostino Di Francesco, Jorge Neves, Tahereh Niknejad, Catarina Ortigão, Manuel Dionísio Rolo, José C. Silva, Rui Silva, Stefaan Tavernier, Viesturs Veckalns, Carlos Zorraquino, Joao Varela, IEEE conference on Nuclear science and medical imaging, 2014, Seatle WA.

-Design and Performance of an ASIC for TOF applications (PDF), Ricardo Bugalho, Manuel Dionisio Rolo, Carlos Zorraquino, Rui Silva, Jose C. Silva, Richard Wheadon, Angelo Rivetti, Stefaan Tavernier, Joao Varela, Viesturs Veckalns, IEEE conference on Nuclear science and medical imaging, 2013, Seoul, Korea

-A 64-channel ASIC for TOFPET applicattions (PDF), M D Rolo, R Bugalho, F Gonçalves, G Mazza, A Rivetti, J C Silva, R Silva and J Varela, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Image-based data corrections for Positron Emission Mammography (PDF), Nuno C. Ferreira, Fabiana Rodrigues, Luís Martins, Catarina Ortigão, Francisco Caramelo, Luís Mendes, Cláudia S. Ferreira, Pedro Almeida, Miguel Castelo-Branco, and João Varela, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Random Correction Method for Positron Emission Mammography Using Delayed Coincidence Data, Liji Cao, Ricardo Bugalho, Catarina Ortigao, Joao Varela, and Jorg Peter, IEEE conference on Nuclear science and medical imaging , 2012, Anaheim CA

-Breast Cancer Diagnosis: First Clinical Results with ClearPEM-Sonic, the Multimodal Positron Emission Mammograph and Ultrasound Scanner, Tessonnier, L.; Siles, P.; Frisch, B.; et al. October 2012. Publication of the abstract in a special series of the EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING: abstract book for the Annual Congress of the EANM 2012, Milan, Italy (Volume: 39 Supplement: 2 Pages: S295-S296 Meeting Abstract: OP696 Published: OCT 2012).

-ClearPEM scanners: performance results and studies in preclinical environment, M. Abrantes, P. Almeida, F. Botelho, R. Bugalho, S. Carvalho, C. S. Ferreira, N. C. Ferreira, M. V. Martins, N. Matela, J. A. Neves, C. Ortigão, A. Rodrigues,A.S. Rodrigues, M. Rolo, J. C. Silva, R. Silva, J. Varela, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-List-Mode Maximum-Likelihood Reconstruction for the ClearPEM System, Liji Cao, Ricardo Bugalho, Nuno Matela, Mónica Martins, Pedro Almeida, Jorg Peter, and Joao Varela, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-Assessment of DOI Resolution in a Fully Mounted PEM Scanner (PDF), N. Matela, C. S. Ferreira1, M. V. Martins, R. Bugalho, J. A. Neves, C. Ortigão, N. Oliveira, J. Varela, P. Almeida, conference proceedings IEEE11 Nuclear Science Symposium and Medical Imaging Conference, Valencia, October 24-30, 2011

-Characterization of the Clear-PEM Breast Imaging Scanner Performance, E. Albuquerque et al., IEEE09 Nuclear Science Symposium and Medical Imaging Conference, Orlando, October 25-31, 2009

-Development of component-based normalization correction for the Clear-PEM system (PDF), C. Guerreiro, N. C. Ferreira, R. Bugalho, A. Trindade, N. Matela, M. V. Martins, L. Mendes, C. S. Ferreira, P. Almeida, J. Varela, IEEE09 Nuclear Science Symposium and Medical Imaging Conference, Orlando, October 25-31, 2009

-High-Speed Data Acquisition Electronics for a PEM Scanner (PDF), P. Lousã et al., IEEE NPSS Real Time Conference, May 10-15, 2009, Beijing, China

-Performance Evalution of a Highly Integrated ADP/ASIC Double Readout Supermodule with 768 Channels for Clear-PEM, E. Albuquerque et al., IEEE08 Nuclear Science Symposium and Medical Imaging Conference, Dresden, October 20-24, 2008